Biochemistry
Glycation
Definition
Glycation is the non-enzymatic covalent bonding of a sugar molecule to a protein or lipid, forming advanced glycation end-products (AGEs). AGE accumulation accelerates with age and in diabetes, contributing to tissue stiffness, chronic inflammation, and oxidative stress. Carnosine is a notable anti-glycation dipeptide that scavenges reactive carbonyl species and prevents AGE formation, which is particularly relevant to diabetic complications and skin aging.
Related Terms
Related Studies
The protective role of carnosine against type 2 diabetes-induced cognitive impairment
Wang Q, Tripodi N, Valiukas Z, et al. · Food Science & Nutrition (2024)
Zinc, carnosine, and neurodegenerative diseases
Kawahara M, Tanaka KI, Kato-Negishi M · Nutrients (2018)
The biological role of carnosine and its possible applications in medicine
Budzeń S, Rymaszewska J · Advances in Clinical and Experimental Medicine (2013)