Zinc, carnosine, and neurodegenerative diseases
Summary
Reviewed evidence linking zinc homeostasis disruption to Alzheimer's disease, vascular dementia, and prion diseases, and carnosine's protective role through antioxidant, metal chelating, anti-crosslinking, and anti-glycation activities. The zinc-carnosine complex (polaprezinc) is already clinically used for zinc supplementation.
Key Findings
- Carnosine protects against neurodegenerative diseases through multiple mechanisms including metal chelation
- Zinc-carnosine complex (polaprezinc) is clinically established for zinc supplementation and ulcer treatment
- Dietary carnosine supplementation shows neuroprotective effects in animal models
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