Collagen
Definition
Collagen is the most abundant structural protein in the human body, comprising approximately 30% of total protein content, and is the primary component of connective tissues including skin, tendons, ligaments, cartilage, and bone. The collagen superfamily includes at least 28 types, with types I, II, and III being the most prevalent. Collagen is characterized by its triple-helix structure formed by three polypeptide chains rich in glycine-proline-hydroxyproline repeats. Collagen synthesis declines with age and is impaired by oxidative stress, UV radiation, and inflammation. The tripeptide GHK-Cu has been shown to stimulate collagen synthesis and remodeling in dermatological and wound-healing research.
Related Terms
Related Compounds
Related Studies
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Pickart L, Vasquez-Soltero JM, Margolina A. · BioMed Research International (2015)
The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health
Pickart L, Vasquez-Soltero JM, Margolina A · Oxidative Medicine and Cellular Longevity (2012)
In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds
Maquart FX, Pickart L, Laurent M, et al. · Journal of Clinical Investigation (1993)