Alpine Research Labs
    cell-biology

    Cellular Senescence

    Definition

    Cellular senescence is a state of irreversible cell cycle arrest in which cells remain metabolically active but cease dividing. Senescent cells accumulate with age and secrete pro-inflammatory cytokines, chemokines, and proteases collectively known as the senescence-associated secretory phenotype (SASP), contributing to chronic inflammation and tissue dysfunction. Senolytic peptides like FOXO4-DRI target senescent cells for elimination as a potential anti-aging strategy.

    Related Terms

    Apoptosis Oxidative Stress Telomere

    Related Compounds

    FOXO4-DRI

    An in-depth review of FOXO4-DRI, a D-retro-inverso senolytic peptide that selectively induces apoptosis in senescent cells by disrupting the FOXO4-p53 nuclear interaction. This monograph covers its mechanism of action, pharmacological properties, and preclinical research across aging, tissue rejuvenation, and cancer senescence models.

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    Related Studies

    FOXO4-DRI regulates endothelial cell senescence via P53 signaling pathway

    Hu Z, Chen Y, Li W, et al. · Frontiers in Bioengineering and Biotechnology (2025)

    FOXO4-DRI induces apoptosis of senescent fibroblasts in keloid tissue

    Kong YX, Zhang L, Wang H, et al. · Communications Biology (2025)

    Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging

    Baar MP, Braat RMC, Putavet DA, et al. · Cell (2017)

    More cell-biology Terms

    AMP-Activated Protein Kinase (AMPK) Apoptosis Autophagy Blood-Brain Barrier (BBB) Epigenetics Erythropoietin Receptor (EPOR) Ferroptosis Fibroblast
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