cell-biology

Erythropoietin Receptor (EPOR)

Definition

The erythropoietin receptor (EPOR) is a cytokine receptor that, when activated by erythropoietin (EPO), promotes red blood cell production. A heterodimer of EPOR with the beta common receptor (betacR/CD131) forms the innate repair receptor (IRR), which mediates tissue-protective and anti-inflammatory effects distinct from erythropoiesis. ARA-290 (cibinetide) selectively activates the IRR without stimulating red blood cell production, providing neuroprotective and anti-inflammatory benefits.

Related Terms

Signal Transduction Neuroprotection

Related Compounds

ARA-290

An in-depth review of ARA-290 (Cibinetide), an 11-amino acid peptide derived from the B helix of erythropoietin that selectively activates the Innate Repair Receptor (IRR) to mediate tissue protection, anti-inflammatory signaling, and nerve fiber regeneration without erythropoietic activity.

Read monograph

Related Studies

Erythropoietin-derived peptide ARA290 mediates brain tissue protection through the beta-common receptor in mice with cerebral ischemic stroke

Wang RL, Yang ZH, Huang YY, et al. · CNS Neuroscience & Therapeutics (2024)

Erythropoietin-derived nonerythropoietic peptide ameliorates experimental autoimmune neuritis by inflammation suppression and tissue protection

Liu Y, Luo B, Han F, et al. · PLoS ONE (2014)

The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model

Pulman KGT, Smith M, Mengozzi M, et al. · Neuroscience (2013)

More cell-biology Terms

AMP-Activated Protein Kinase (AMPK) Apoptosis Autophagy Blood-Brain Barrier (BBB) Cellular Senescence Epigenetics Ferroptosis Fibroblast

Back to Full Glossary