Ferroptosis
Definition
Ferroptosis is a form of regulated cell death driven by iron-dependent lipid peroxidation, distinct from apoptosis, necrosis, and autophagy. It is characterized by accumulation of lipid reactive oxygen species and depletion of glutathione peroxidase 4 (GPX4). Ferroptosis has been implicated in neurodegeneration, cardiac injury, and cancer. Thymosin beta-4 (TB-500) has been studied for its ability to inhibit ferroptosis in cardiac tissue models.
Related Terms
Related Compounds
TB-500
A comprehensive review of TB-500, a synthetic fragment of Thymosin Beta-4, examining its role in wound healing, tissue regeneration, and inflammation research.
Read monographGlutathione
An in-depth review of glutathione (GSH), the body's most abundant intracellular antioxidant tripeptide, covering its mechanism of action, redox cycling, conjugation reactions, enzyme systems, pharmacokinetics, oral bioavailability challenges, research applications in oxidative stress protection, detoxification, liver health, immune support, safety profile, and dosing in research.
Read monographRelated Studies
Thymosin beta 4 is an endogenous iron chelator and molecular switch of ferroptosis
Lachowicz JI, Pichiri G, Piludu M, et al. · Pharmacological Research (2022)
Glutathione: overview of its protective roles, measurement, and biosynthesis
Forman HJ, Zhang H, Rinna A · Molecular Aspects of Medicine (2009)
Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Bock-Marquette I, Saxena A, White MD, et al. · Nature (2004)
Thymosin beta4 promotes dermal hair follicle neogenesis
Philp D, Nguyen M, Scheremeta B, et al. · FASEB Journal (2004)