Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging
Summary
Landmark study demonstrating that FOXO4-DRI selectively induces apoptosis in senescent cells by disrupting the FOXO4/p53 interaction that maintains senescent cell viability. Treatment restored tissue homeostasis, improved organ function, and reversed age-related phenotypes in naturally aged mice.
Key Findings
- FOXO4-DRI selectively induced apoptosis in senescent cells while sparing healthy cells
- Disrupted FOXO4/p53 nuclear interaction that maintains senescent cell survival
- Restored fitness, fur density, and renal function in naturally aged mice
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