Satellite Cell
Definition
Satellite cells are quiescent muscle stem cells located between the sarcolemma and basal lamina of skeletal muscle fibers. Upon activation by injury or growth signals, satellite cells proliferate, differentiate into myoblasts, and fuse with existing muscle fibers to enable repair and hypertrophy. Follistatin promotes satellite cell activation by antagonizing myostatin, and TB-500 (thymosin beta-4) supports muscle repair partly through effects on progenitor cell migration.
Related Terms
Related Compounds
Follistatin
An in-depth review of Follistatin (FST-344), covering its isoforms, mechanism of myostatin and activin neutralization, gene therapy applications for muscular dystrophies, metabolic effects, and clinical trial data.
Read monographTB-500
A comprehensive review of TB-500, a synthetic fragment of Thymosin Beta-4, examining its role in wound healing, tissue regeneration, and inflammation research.
Read monographRelated Studies
Thymosin beta 4 is an endogenous iron chelator and molecular switch of ferroptosis
Lachowicz JI, Pichiri G, Piludu M, et al. · Pharmacological Research (2022)
Follistatin gene delivery enhances muscle growth and strength in nonhuman primates
Kota J, Handy CR, Haidet AM, et al. · Science Translational Medicine (2009)
Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin
Gilson H, Schakman O, Kalista S, et al. · American Journal of Physiology-Endocrinology and Metabolism (2009)
Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Bock-Marquette I, Saxena A, White MD, et al. · Nature (2004)