Alpine Research Labs
    endocrinology

    Myostatin

    Definition

    Myostatin (also known as growth differentiation factor 8, GDF-8) is a member of the TGF-beta superfamily that acts as a negative regulator of skeletal muscle mass. Myostatin signals through activin type II receptors to inhibit myoblast proliferation and satellite cell activation. Follistatin is a natural myostatin antagonist that binds and neutralizes myostatin, and research into myostatin inhibition has significant implications for muscle wasting conditions and age-related sarcopenia.

    Related Terms

    Satellite Cell

    Related Compounds

    Follistatin

    An in-depth review of Follistatin (FST-344), covering its isoforms, mechanism of myostatin and activin neutralization, gene therapy applications for muscular dystrophies, metabolic effects, and clinical trial data.

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    Related Studies

    Follistatin gene delivery enhances muscle growth and strength in nonhuman primates

    Kota J, Handy CR, Haidet AM, et al. · Science Translational Medicine (2009)

    Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin

    Gilson H, Schakman O, Kalista S, et al. · American Journal of Physiology-Endocrinology and Metabolism (2009)

    Regulation of myostatin activity and muscle growth

    Lee SJ, McPherron AC · Proceedings of the National Academy of Sciences (2001)

    More endocrinology Terms

    Circadian Rhythm Ghrelin Receptor (GHS-R1a) Growth Hormone Secretagogue (GHS) Hypothalamic-Pituitary Axis Insulin Resistance
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