Vascular Endothelial Growth Factor (VEGF)
Definition
Vascular Endothelial Growth Factor (VEGF) is a family of signaling glycoproteins (VEGF-A, VEGF-B, VEGF-C, VEGF-D, PlGF) that are key regulators of angiogenesis, vasculogenesis, and vascular permeability. VEGF-A, the most studied isoform, binds to VEGFR-1 and VEGFR-2 tyrosine kinase receptors on endothelial cells, triggering signaling cascades that promote endothelial cell proliferation, migration, and tube formation. BPC-157 has been shown to upregulate VEGF expression in multiple tissue injury models, contributing to its observed wound-healing and tissue-protective properties.
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Related Studies
Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and leads to functional recovery in rats
Perovic D, Kolenc D, Bilic V, et al. · Journal of Orthopaedic Surgery and Research (2019)
Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
Sikiric P, Rucman R, Turkovic B, et al. · Current Neuropharmacology (2017)
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
Chang CH, Tsai WC, Lin MS, et al. · Molecules (2014)
Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract
Sikiric P, Seiwerth S, Rucman R, et al. · Current Pharmaceutical Design (2011)