Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
Sikiric P, Rucman R, Turkovic B, et al.
Current Neuropharmacology
Summary
Comprehensive review establishing BPC 157 as a brain-gut peptide with bidirectional effects along the brain-gut axis. Discusses interactions with the dopaminergic, serotonergic, GABAergic, and opioid systems.
Key Findings
- BPC 157 modulates both central and peripheral neurotransmitter systems via the brain-gut axis
- Demonstrated counteraction of dopamine system disturbances in multiple animal models
- Proposed as a unique agent that integrates GI protection with CNS effects
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DOI: 10.1002/jor.21107