Alpine Research Labs
    Pharmacology

    Senolytic

    Definition

    A senolytic is any agent that selectively induces apoptosis in senescent cells while sparing healthy, non-senescent cells. By clearing accumulated senescent cells, senolytics aim to reduce the burden of the senescence-associated secretory phenotype (SASP) and restore tissue function. The peptide FOXO4-DRI is a notable senolytic that works by disrupting the FOXO4-p53 interaction that maintains senescent cell survival.

    Related Terms

    Cellular Senescence Apoptosis

    Related Compounds

    FOXO4-DRI

    An in-depth review of FOXO4-DRI, a D-retro-inverso senolytic peptide that selectively induces apoptosis in senescent cells by disrupting the FOXO4-p53 nuclear interaction. This monograph covers its mechanism of action, pharmacological properties, and preclinical research across aging, tissue rejuvenation, and cancer senescence models.

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    Related Studies

    FOXO4-DRI regulates endothelial cell senescence via P53 signaling pathway

    Hu Z, Chen Y, Li W, et al. · Frontiers in Bioengineering and Biotechnology (2025)

    FOXO4-DRI induces apoptosis of senescent fibroblasts in keloid tissue

    Kong YX, Zhang L, Wang H, et al. · Communications Biology (2025)

    Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging

    Baar MP, Braat RMC, Putavet DA, et al. · Cell (2017)

    More Pharmacology Terms

    Bioavailability Dose-Response Curve EC50 (Half-Maximal Effective Concentration) Exercise Mimetic First-Pass Metabolism Growth Hormone-Releasing Peptides (GHRPs) Half-Life IC50 (Half-Maximal Inhibitory Concentration)
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