Neurotrophic Factor
Definition
Neurotrophic factors are a family of secreted proteins that promote the survival, development, and function of neurons. Key neurotrophic factors include brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and hepatocyte growth factor (HGF). Several research peptides modulate neurotrophic factor expression — Semax upregulates BDNF and NGF, Cerebrolysin contains neurotrophic peptide fragments, and Dihexa activates the HGF/c-Met system.
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Related Compounds
Semax
An in-depth review of Semax, a synthetic ACTH(4-10) analog, examining its nootropic properties, BDNF and NGF upregulation, neuroprotective mechanisms, and applications in cognitive enhancement research.
Read monographCerebrolysin
A detailed research review of Cerebrolysin, a porcine brain-derived neuropeptide preparation with neurotrophic and neuroprotective properties studied in stroke, Alzheimer's disease, and TBI.
Read monographDihexa
An in-depth review of Dihexa, a potent angiotensin IV analog and HGF/c-Met signaling activator, examining its role in synaptogenesis, cognitive enhancement, neuroplasticity, and dementia-related research.
Read monographRelated Studies
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-induced Huntington's Disease-Like Symptoms in Rats
Wells RG, Yamamoto BK, Wright JW, et al. · Journal of Huntington's Disease (2024)
Antidepressant-like and antistress effects of Semax in rats subjected to chronic unpredictable stress
Inozemtseva LS, Karpenko EA, Dolotov OV, et al. · European Journal of Pharmacology (2024)
Cerebrolysin reduces astrogliosis and axonal injury and enhances neurogenesis in rats after closed head injury
Zhang Y, Chopp M, Zhang ZG, et al. · Neurorehabilitation and Neural Repair (2019)
Cerebrolysin: a multi-target drug for recovery after stroke
Brainin M · Expert Review of Neurotherapeutics (2018)