Hepatocyte Growth Factor (HGF)
Definition
Hepatocyte Growth Factor (HGF) is a paracrine growth factor that binds to the c-Met receptor tyrosine kinase to regulate cell growth, motility, morphogenesis, and tissue regeneration across multiple organ systems. Originally identified for its role in liver regeneration, HGF/c-Met signaling has since been shown to be critical for neuronal survival, synaptic plasticity, and cognitive function. The small molecule peptide dihexa was designed as an HGF/c-Met system modulator and has demonstrated potent procognitive effects in animal models by augmenting HGF-mediated neurotrophic signaling.
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Related Studies
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-induced Huntington's Disease-Like Symptoms in Rats
Wells RG, Yamamoto BK, Wright JW, et al. · Journal of Huntington's Disease (2024)
Procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
Benoist CC, Kawas LH, Zhu M, et al. · Journal of Pharmacology and Experimental Therapeutics (2014)
A novel angiotensin IV/AT4 receptor ligand, Nle1-AngIV (dihexa), is a potent procognitive agent that augments hepatocyte growth factor (HGF)/Met signaling
McCoy AT, Benoist CC, Wright JW, et al. · Journal of Pharmacology and Experimental Therapeutics (2013)