Antidepressant-like and antistress effects of Semax in rats subjected to chronic unpredictable stress
Inozemtseva LS, Karpenko EA, Dolotov OV, et al.
European Journal of Pharmacology
Summary
Demonstrated that intranasal Semax reversed chronic unpredictable stress-induced anhedonia in rats and restored hippocampal BDNF levels depleted by chronic stress. Supports Semax as a potential antidepressant agent acting through restoration of stress-depleted neurotrophic signaling.
Key Findings
- Semax reversed anhedonia caused by chronic unpredictable stress in rats
- Restored hippocampal BDNF levels that were depleted by chronic stress exposure
- Supports potential antidepressant application through neurotrophic mechanism restoration
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