Intranasal Delivery
Definition
Intranasal delivery is a non-invasive route of administration in which a substance is applied to the nasal mucosa, allowing absorption through the highly vascularized nasal epithelium into systemic circulation. This route bypasses first-pass hepatic metabolism and, importantly for neuropeptides, may provide a direct nose-to-brain pathway via the olfactory and trigeminal nerve pathways that circumvents the blood-brain barrier. Several research peptides including semax, selank, and oxytocin have been formulated for intranasal delivery to target central nervous system effects more directly.
Related Terms
Related Compounds
Semax
An in-depth review of Semax, a synthetic ACTH(4-10) analog, examining its nootropic properties, BDNF and NGF upregulation, neuroprotective mechanisms, and applications in cognitive enhancement research.
Read monographSelank
An in-depth review of Selank, a synthetic tuftsin analog heptapeptide, covering its anxiolytic mechanisms, cognitive enhancement potential, GABA modulation, immunomodulatory properties, and key published research findings.
Read monographRelated Studies
Antidepressant-like and antistress effects of Semax in rats subjected to chronic unpredictable stress
Inozemtseva LS, Karpenko EA, Dolotov OV, et al. · European Journal of Pharmacology (2024)
Selank: a short peptide with anxiolytic-like properties
Zozulya AA, Sizov OB, Seredenin SB · Bulletin of Experimental Biology and Medicine (2008)
Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH 4-10
Agapova TY, Agniullin YV, Silachev DN, et al. · Neuroscience Letters (2007)
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. · Brain Research (2006)