Formulation
Lipidation
Definition
Lipidation is the covalent attachment of a fatty acid chain to a peptide, typically to promote non-covalent binding to serum albumin and thereby extend the circulating half-life. This approach is central to the design of long-acting GLP-1 receptor agonists — semaglutide features a C18 fatty diacid linker that enables once-weekly dosing by dramatically slowing renal clearance and proteolytic degradation.