Clinical Trial
Definition
A clinical trial is a structured research study conducted in human participants to evaluate the safety, efficacy, dosing, and side effects of a medical intervention. Clinical trials proceed through phases: Phase I (safety and dosing in small groups), Phase II (efficacy and side effects), Phase III (large-scale efficacy confirmation), and Phase IV (post-market surveillance). Peptides like semaglutide and tirzepatide have completed full clinical trial programs leading to regulatory approval.
Related Terms
Related Compounds
Semaglutide
An in-depth review of Semaglutide, a long-acting GLP-1 receptor agonist, covering its mechanism of action, albumin-binding pharmacokinetics, and research applications in metabolic health, weight management, and cardiovascular outcomes.
Read monographTirzepatide
An in-depth review of Tirzepatide, the first dual GIP/GLP-1 receptor agonist ('twincretin'), examining its mechanism of action, superior glycemic and weight loss efficacy, and research applications in metabolic health.
Read monographRelated Studies
Tirzepatide Once Weekly for the Treatment of Obesity
Jastreboff AM, Aronne LJ, Ahmad NN, et al. · New England Journal of Medicine (2022)
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Wilding JPH, Batterham RL, Calanna S, et al. · New England Journal of Medicine (2021)
Efficacy and Safety of Tirzepatide Monotherapy in Type 2 Diabetes (SURPASS-1)
Rosenstock J, Wysham C, Frias JP, et al. · New England Journal of Medicine (2021)
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Marso SP, Bain SC, Consoli A, et al. · New England Journal of Medicine (2016)