Synthetic ERR alpha/beta/gamma agonist induces an ERR-alpha-dependent acute aerobic exercise response and enhances exercise capacity
Summary
First characterization of SLU-PP-332 as a pan-ERR agonist with highest potency for ERR-alpha. Administration to mice increased type IIa oxidative skeletal muscle fibers, enhanced exercise endurance, and activated an acute aerobic exercise genetic program — establishing it as a pharmacological exercise mimetic.
Key Findings
- SLU-PP-332 is a first-in-class pan-ERR agonist targeting all three ERR subtypes
- Increased type IIa oxidative muscle fibers and enhanced exercise endurance in mice
- Activated an ERR-alpha-dependent acute aerobic exercise transcriptional program
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