MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling Pathway in Diabetic Rats
Summary
Showed that MOTS-c treatment restores cardiac function in diabetic rats through activation of the NRG1-ErbB4 signaling pathway. MOTS-c improved cardiac structure and function comparably to exercise, and the combination of MOTS-c plus exercise produced additive cardioprotective benefits.
Key Findings
- MOTS-c restored cardiac function in diabetic rats via NRG1-ErbB4 pathway activation
- Effects were comparable to those achieved by exercise alone
- Combined MOTS-c and exercise produced additive cardioprotective benefits
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