Completed Preclinical (in vitro) 2024
Liposome encapsulation of the palmitoyl-KTTKS peptide: structural and functional characterization
Summary
Characterized palmitoyl-KTTKS (Matrixyl) in liposomal delivery systems and demonstrated enhanced collagen stimulation in fibroblast cultures. When delivered via phospholipid vesicles, pal-KTTKS stimulated collagen production more effectively than free peptide or ascorbic acid positive control.
Key Findings
- Liposome-delivered pal-KTTKS stimulated greater collagen production than free peptide
- Outperformed 1 mM ascorbic acid (positive control) for collagen synthesis stimulation
- Liposomal formulation improved peptide stability and cellular delivery
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