Anti-inflammatory effect of the growth hormone-releasing peptide, GHRP-2, in arthritic rats
Granado M, Priego T, Martín AI, et al.
American Journal of Physiology-Endocrinology and Metabolism
Summary
Demonstrated that GHRP-2 exerts significant anti-inflammatory effects in an adjuvant-induced arthritis rat model. Treatment reduced circulating inflammatory markers and attenuated arthritis-induced muscle wasting, suggesting therapeutic potential beyond growth hormone secretion.
Key Findings
- GHRP-2 significantly reduced inflammation in adjuvant-induced arthritis model
- Attenuated arthritis-induced body weight loss and muscle wasting
- Decreased circulating levels of pro-inflammatory cytokines
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